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The Role of Vitamin D in The Age of C-19

Evidence recommends that vitamin D might be a crucial supportive agent for the immune system, mainly in cytokine response regulation against COVID-19. Hence, we carried out a systematic review and meta-analysis in order to maximize the use of everything that exists about the role of vitamin D in the COVID-19


Method: Meta Analysis: Studies focused on the role of vitamin D in confirmed COVID-19 patients were entered into the systematic review.


Results Sixteen studies containing 4922 participants entered into the meta-analysis. The meta-analysis indicated that 48% of COVID-19 patients were suffering from vitamin D deficiency (95% CI, 29%-67%), and in 41% of patients, levels of vitamin D were insufficient (95% CI, 10%-82%).

Reported ethnic groups in studies were 1.0% Afro-Caribbean, 10.3% Asian, and 92.1% Caucasian.

Conclusion This study found that the mean serum 25-hydroxyvitamin D level was low in all COVID-19 patients, and most of them were suffering from vitamin D deficiency/insufficiency. The Caucasian was the dominant ethnic group, and the most frequent co-morbidities in COVID-19 patients were hypertension, cardiovascular diseases, chronic kidney disease, diabetes, obesity, and respiratory diseases, which might be affected by vitamin D deficiency directly or indirectly.


Paper in collection COVID-19 SARS-CoV-2 preprints from medRxiv and bioRxiv

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